Herein, we investigated the plant-derived isoquinoline alkaloid berberine, which has been reported to have anticancer activity, and synthetic 13-arylalkyl derivatives thereof for their effects
on Wnt/-catenin signaling. Berberine did not show major effects on viability of HEK-293 embryonic kidney and HCT116 colon carcinoma cells and was not toxic in concentrations up to 20 mu M. Berberine inhibited -catenin transcriptional activity and attenuated anchorage-independent growth. As a result of berberine treatment, cellular levels of active -catenin were reduced concomitant with an increase in the expression of E-cadherin. However, in unstimulated cells, the effects on -catenin levels were low. A screen of synthetic 13-arylalkyl berberine derivatives identified compounds exhibiting activities superior selleck products to those of the naturally occurring parent substance with more BAY 80-6946 chemical structure than 100-fold lower EC50 values for Wnt-repression. Thus, berberine and its synthetic derivatives represent potential therapeutic agents to inhibit Wnt/-catenin signaling in tumorigenesis. (c) 2013 BioFactors, 39(6):652-662, 2013″
“Here, we investigated the prevalence of headache among adults in Jordan. The study was conducted from January 2007 to November 2008. A sample of 4,836 participants were permitted to complete a self-conducted screening questionnaire. As much as 82.3% of participants complained from headache at least once per year. 36.1%
were tension-type headache and 59% of the participants had other family members who suffered from headache. Headaches affected everyday activities in 51.6% of the participants; 82.7% of participants did not seek medical attention for their headaches. Among those who used analgesics (75.6%), acetaminophen was the most common (91.43%). In conclusion, headache and overuse selleck chemicals llc of analgesics were prevalent in a significant part of the society. Thus, there is a need to educate the public to ensure safe practices and to make the use and selling of analgesics more stringent.”
“The aim of this study was to evaluate the quality of compounded capsules
of different drugs for chronic diseases. It were assessed two samples, from two different pharmacies, for each of the following drugs: ranitidine 150 mg, methyldopa 250 mg, enalapril maleate 20 mg, fluoxetine hydrochloride 20 mg, propranolol hydrochloride 40 mg, and furosemide 40 mg. The assays of mean weight, content determination, content uniformity and dissolution were performed according to Brazilian Pharmacopoeia. All samples were approved in the assay of mean weight, and the samples M1 and Flu1 had failed in the assay of content determination. In the test of uniformity of dosage units the samples M1, Flu1, E1, E2 and Flu2 had failed. Only the samples M2, P1, P2, F1 and F2 were accepted in all pharmacopoeial tests, evidencing that the others did not achieve the minimum requirements to ensure safety, quality and efficacy of the drugs.