The recently discovered common molecular pathways involved in these processes are discussed.

Summary

AITDs and rheumatologic

disorders have significant commonalities both clinically and etiologically. This information is important for rheumatologists and primary care physicians who care for patients with these disorders.”
“BACKGROUND

Excision of invasive melanoma and melanoma in situ click here (MIS) using variations of the Mohs micrographic surgery (MMS) technique is becoming increasingly common in difficult areas, such as the periocular area, where standard surgical margins may not be feasible, and clinical margins are poorly defined. However, little long-term data evaluating the treatment of periocular melanoma are available in the literature.

OBJECTIVE

To present our long-term experience in the treatment of periocular melanoma

using a staged, modified Mohs excision technique with rush permanent, paraffin-embedded tissue sections.

MATERIALS AND METHODS

A total of 35 patients with periocular melanoma and MIS were treated using modified MMS during a 15-year period. Twenty-nine patients were available with adequate follow-up of greater than 5 years duration. The mean follow-up duration was 94 months.

RESULTS

There were a total of five recurrences (17.2%) detected an average of 85 months after excision. Four of the five recurrent tumors had GDC-0994 been previously excised. The recurrence rate for primary tumors was 5% (1/20). The recurrence rate for previously excised tumors was 44.4% (4/9).

CONCLUSION

Margin-control surgery is favored in the treatment of periocular melanoma to maximize the cure rate and minimize postoperative morbidity by sparing normal tissue. Ample follow-up intervals are required to adequately assess recurrence rates. The best opportunity for cure is associated with the first tumor excision.

The authors have indicated no significant interest with

commercial supporters.”
“OBJECTIVE: Recurrent pelvic organ prolapse (POP) has been attributed to many factors, one of which is lack of vaginal apical support. To assess the role of vaginal apical support and POP, we analyzed a national dataset to compare long-term reoperation rates after prolapse ABT-888 in vitro surgery performed with and without apical support.

METHODS: Public use file data on a 5% random national sample of female Medicare beneficiaries were obtained from the Centers for Medicare and Medicaid Services. Women with POP who underwent surgery during 1999 were identified by relevant International Classification of Diseases, 9th Revision, Clinical Modification, and Current Procedural Terminology, Fourth Edition codes. Individual patients were followed-up through 2009. Prolapse repair was categorized as anterior, posterior, or anterior-posterior with or without a concomitant apical suspension procedure. The primary outcome was the rate of retreatment for POP.

RESULTS: In 1999, 21,245 women had a diagnosis of POP. Of these, 3,244 (15.