The aim of this study was to examine the relationship between CrCI, CYST, beta(2)-microglobulin (B2M) and TATI, with glomerular
filtration rate (GFR) in patients with different levels of proteinuria.
Methods: Seventy-one patients (37 males, 34 females, mean age 53 +/- selleck products 15 years) were included in the study. GFR was measured by the bladder cumulative method using Tc-99m-DTPA. Blood levels of CYST, B2M and TATI were also measured. CrCI and proteinuria were determined by 24-hour urine collection. Statistical analysis was performed with multivariate analysis.
Results: The results are expressed as the ratio to GFR of CrCI and reciprocals of CYST (100/CYST), B2M (100/B2M) and TATI (100/TATI). The ratio CrCI/GFR increased from 1.41 in patients with proteinuria <1 g/ day, to 1.66 (p<0.05) in those with proteinuria >3 g/day. 1 The ratio 100/CYST/GFR selleck chemicals llc was 1.67 and 2.28 (p<0.05), 100/B2M/GFR 0.90 and 0.69 and 100/TATI/GFR 0.14 and 0.19, respectively. Multivariate analysis demonstrated that CICr/GFR as well
as 100/CYST/GFR was independently related to the degree of proteinuria.
Conclusions: CrCI and CYST overestimate GFR in patients with heavy proteinuria, while the ratios 100/TATI and 100/B2M with GFR do not significantly change. The direct measurement of GFR still remains the best method to assess the progression of renal damage in patients with heavy proteinuria.”
“P>We Crenigacestat chemical structure describe the case of a neonate who underwent surgery for bowel obstruction. The child was born at 25 weeks postconception, and at the time of surgery, he had a postconceptual age of 44 weeks. He had undergone two previous laparotomy procedures for necrotizing enterocolitis. At laparotomy, there was unexpected extensive compromise to gut perfusion. The child developed ventricular fibrillation following the reperfusion of a segment of ischemic
gut found incarcerated in an inguinal hernial orifice. We discuss the pathophysiology of intestinal ischemia-reperfusion (I-R) injury. We have reviewed the interventions that may be employed to minimize the systemic impact of I-R.”
“Background: Vitamin D (vitD) insufficiency is common in end-stage renal disease. Seasonal and ethnic differences in vitD status have been reported previously. We hypothesized that vitD status in Afro-Caribbean patients on hemodialysis (HD) living in a country with a constant sunny climate would be better than that in African-American HD patients living in countries with a winter season.
Method: A cross-sectional study was conducted in 152 Afro-Caribbean HD patients in a dialysis center located in Guadeloupe. We evaluated the prevalence of vitD insufficiency, defined as serum 25-hydroxyvitamin D (25(OH)D) levels below 30 ng/mL, compared with those results previously reported in African-American HD patients (88%).