We report a case of triple fungal infection including an invasive pulmonary aspergillosis by Aspergillus fumigatus, a candidemia by Candida albicans and a Pneumocystis pneumonia. The overall clinical picture of this patient was liver cirrhosis with medical history of immunosuppressive

treatment for Crohn disease and a non-hodgkin lymphoma. There was no antifungal prophylaxis for this patient. Under treatment, the issue was unfavourable with multivisceral failure.”
“Objective To determine whether the ratio of pulse oximetry saturation/fraction of inspired oxygen (SpO2/FiO2, [SF]) correlates with the ratio of partial FK506 pressure of oxygen in arterial blood/FiO2 (PaO2/FiO2, [PF]) in dogs. Design Prospective, observational pilot study. Setting Urban tertiary veterinary referral center. Animals Thirty-eight client-owned dogs requiring assessment of oxygenation. GSK1838705A order Interventions None. Measurements and Main Results Arterial blood gas analysis with co-oximetry was performed on samples obtained from the dorsal pedal artery. Median SpO2 was 91.5% (range 80-97%) and median PaO2 was 70.1 mmHg (range 44.5-103.8 mmHg). Hypoventilation

was uncommon and venous admixture was the predominant cause of hypoxemia in this population. Median SF was 435.7 (range 381.0-461.9) and median PF was 334.0 (range 211.9-494.3). Nine dogs (23.6%) had PF <300; no dogs had PF below 200. SF and PF were correlated ( = 0.618, P < 0.01). Conclusions SF and PF in dogs spontaneously breathing S3I-201 room air have good correlation, suggesting that SF may be a useful, noninvasive surrogate for PF when assessing oxygenation in canine patients.

Further studies are warranted to confirm and validate this relationship in spontaneously breathing and mechanically ventilated dogs on varying levels of FiO2 and to assess the ability of SF to predict outcome.”
“Aims: Adolescence is considered a critical phase for smoking initiation, while smoking initiation in adulthood has received less attention. In the present study, we investigated smoking initiation in early adulthood, with an additional focus on how socioeconomic status (SES) relates to late-onset smoking. Methods: The Norwegian Longitudinal Health Behaviour Study followed a representative sample of adolescents (n=530) from age 13 (7th grade) to age 30 (years 1990-2007) through 9 waves of data collection. Information was collected on the adolescents’ gender, smoking, alcohol use, cannabis use, physical activity, and SES. Those reporting to be smokers at age 30, but not at age 18, were defined as “late-onset smokers”. Results: At age 30, 21% were daily smokers, of which 45% met our definition of late-onset smoking. Participants with a low SES had a higher odds ratio for late-onset smoking (OR=3.42) and a lower odds ratio for quitting smoking (OR=0.40) after adjusting for confounders.