There are 105 upregulated and 51 downregulated DEGs with the Vorinostat cell line above functions. Table 3 The down-regulated DEGs sharing from cirrhosis to metastasis sorted out by the Selleckchem Tucidinostat following GO function. Gene Symbol Gene
Title GO COL18A1 procollagen, type XVIII, alpha 1 1–6 CXCL12 chemokine (C-X-C motif) ligand 12 1,2,4,5 KDR kinase insert domain protein receptor 1,4,6 SERPINA3K serine (or cysteine) peptidase inhibitor, clade A, member 3K 1,2,5 ANG1 angiogenin, ribonuclease A family, member 1 1,5 RNASE4 ribonuclease, RNase A family 4 1,5 C5 complement component 5 2,4 CML4 Camello-like 4 3 ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 3 GPHN gephyrin 3 IGFALS insulin-like growth factor binding protein, acid labile subunit 3 LIN7A lin-7 homolog a (C. elegans) 3 AZGP1 alpha-2-glycoprotein 1, zinc 3,5 PROC Protein C 2 PTPRD protein tyrosine phosphatase, receptor type, D 3 PVRL3_predicted poliovirus receptor-related 3 (predicted) 3 SORL1 sortilin-related receptor, LDLR class A repeats-containing
4,5 TGFBI transforming VS-4718 growth factor, beta induced 3,4,6 RB1 retinoblastoma 1 2,3,5 EGFR epidermal growth factor receptor 2–6 EGF epidermal growth factor 2,5,6 IGF1 Insulin-like growth factor 1 2,5,6 HNF4A Hepatocyte nuclear factor 4, alpha 2,5 BCL6_PREDICTED B-cell leukemia 6 (predicted) 2,5 PEMT phosphatidylethanolamine N-methyltransferase 2,5 LRP1 low density lipoprotein receptor-related protein 1 2,5 RGN regucalcin 2,5 SGPP1 sphingosine-1-phosphate phosphatase 1 2 NR1D2 nuclear receptor subfamily 1, group D, member 2 2 GHR Growth hormone receptor 2 CYP2E1 cytochrome P450, family 2, subfamily e, polypeptide 1 2 C4BPB complement component 4 binding protein,
beta 2 C6 complement component 6 2 FAAH fatty acid amide hydrolase 2 NR0B2 nuclear receptor subfamily 0, group B, member 2 2 PCSK9 proprotein convertase subtilisin/kexin type 9 2 UNG uracil-DNA glycosylase 2 CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 5 PCAF p300/CBP-associated factor 5 CFB complement factor B 5 DBP D site albumin promoter binding protein mafosfamide 5 ADRA1B adrenergic receptor, alpha 1b 5 FABP1 fatty acid binding protein 1, liver 5 VIPR1 vasoactive intestinal peptide receptor 1 5 ID4 Inhibitor of DNA binding 4 5 NOX4 NADPH oxidase 4 5 AMY1 amylase 1, salivary 6 GPLD1 glycosylphosphatidylinositol specific phospholipase D1 6 SMOC1 SPARC-related modular calcium binding protein 1 6 NOTE: The numbers from 1–6 indicate GO terms: angiogenesis, apoptosis, cell adhesion, cell migration, cell proliferation and extracellular matrix, respectively. The rat models of liver cancer induced by DEN occurred following chronic injury, regenetation, fiborsis and cirrhosis. Elements of the inflammatory response, immune response and oxidative stress were also involved in the process of hepatocarcinogenesis. Tables 4 and 5 show that the expression of 40 such genes was upregulated and the expression of 27 genes was downregulated.