Sylvain Rheims, Department of Functional Neurology and Epileptology, Neurological Hospital, CTRS-INSERM IDEE (Institut Des Epilepsies de l’Enfant et de VRT752271 molecular weight l’adolescent), Hospices Civils de Lyon, INSERM U821, Université Claude Bernard

Lyon 1, Lyon, France.
The majority of epileptic disorders are not self-limiting over time, and therefore require a long-lasting and often even lifelong antiepileptic drug (AED) treatment, in Wi/omen with epilepsy, the influence of their disease on the possibility and course of pregnancies, as well as the potential impact Inhibitors,research,lifescience,medical of the AED

treatment on mother and child, are crucial questions. This Inhibitors,research,lifescience,medical review addresses the clinically relevant knovledge concerning the impact of the disease itself and the AED treatment on fertility, pregnancy, delivery, the postpartum period, and teratogenicity. Some of the new AEDs appear to have a favorable profile due to a lack of clinically relevant interactions and promising teratogenic profiles. However, the finding of decreases in lamotrigine serum concentrations during hormonal contraception and pregnancy Inhibitors,research,lifescience,medical is an instructive example, shovt/ing that ongoing studies are urgently needed to further investigate stillunanswered questions. Several prospective multinational Inhibitors,research,lifescience,medical surveys are currently being performed, and should add essential information in this context. Keywords: epilepsy, antiepileptic drug, fertility, interaction, pregnancy, delivery, puerperium, teratogenicity Inhibitors,research,lifescience,medical Abstract La mayoría de los trastornos epilépticos no son autolimitados a to largo del tiempo,y

por lo tanto requieren de un tratamiento de larga duración y a menudo de por vida con fármacos antiepilépticos (FAE), En las mujeres con epilepsia consiituyen temas cruciales la influencia de la enfermedacl en la posibilidad que ocurra Metalloexopeptidase el embarazo y en el curso de este, como también el potencial impacto del tratamiento con FAE en la madré y en el niño. Esta revisión aborda el conocimienio de relevancia clfnica relacionado con el impacto de la enfermedad y del tratamiento con FAE en la fertilidad, el embarazo, el parto, el perfodo del postparto y la teratogeneidad, Algunos de los nuevos FAE parecen tener un perfil favorable debido a la falta de interacciones clínicamente relevantes y a prometedores perfiles teratogénicos.