In the combination group, suggesting synergy between SC 203 048 and PTL. All show that SC can be combined with PTL 203 048 k Nnten be an effective therapeutic strategy for AML. To study the molecular mechanism of the SC 203 048 and PLT inhibit the growth and apoptosis of tumor xenograft THP-1, several genes have been detected. Cyclin D1 is an essential factor in the transition from G0/G1 to S phase of the cell cycle, and is also an object of NF B in controlled κ Of the cell cycle. In this study, downregulation of cyclin D1 after different treatments, especially observed in the combination group. It shows that the downregulation of cyclin D1 by SC 203 048 or PTL may be a factor for the inhibition of tumor growth to be. SMRT is one of the h Silodosin adrenergic receptor inhibitor Ufigsten factors and transcriptional repression plays a role The role in various cancer diseases. Our previous studies have shown that decreased expression of SMRT in a cell line THP exist, and it is an important molecule downstream signaling pathway FLT3/p65. In the current study, when the negative regulation of p65 expression, increases the expression of core protein ht SMRT fa Is in a tumor xenograft THP, the also represented, k can Make an important signal path significant at tumor growth. Bcl-2 is an important member of the anti-apoptotic Bcl-2 family, and it inhibits the overexpression of cell death induced by stress and f Promotes the survival of cells h Hematopoietic Ethics. Research has shown that several members of the Bcl-2 by NF B are regulated κ In the current study, was down-regulation of Bcl-2 observed after different treatments, especially in the group receiving the combination, suggesting that the downregulation of bcl 2 of SC 203 048 or PTL may be a factor to its cellular apoptosis.
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