D in Table 2 In most of these F Ll preceded HIV diagnosis The diagnosis of APL at least 2 years. In the case presented here, a diagnosis of HIV-competitive, but the duration of infection, which could still be determined S1P Receptors exactly. Sutton and colleagues reported one Hnlichen case of the PLA who were diagnosed simultaneously with HIV.3 was not aware of the above factors anf Make llig, AML has been documented in five of the six reports. In the event, Boban and colleagues, the patient has a previous diagnosis of prim Ren CNS lymphoma in CR irradiation of the brain had together, and eventually developed APL 2 years after Lich completion of therapy.8 The scarcity of cases F Is difficult to establish a clear link between HIV and APL. Infection of macrophages and vascular Was re endothelial cells with both HIV showed that the support functions change in the bone marrow of the other cancer models VER, So that a permissive microenvironment for abnormal cell growth in the absence of Frank infection of malignant stem cells cells.9 In another report , Aboulafia and colleagues postulated that the extracellular re release of trans potent activator protein, Tat, CD4 cells are infected with HIV play a r angiogenesis in the vital, the theory of Ver help change the tumor microenvironment additionally as a factor in the selection leukemogenesis2 tzlich to chronic immune stimulation and deregulation by the virus itself.10 Despite these reports, the precise connection between HIV and APL remains unclear and whether these processes play an R in the onset or progression of APL clones remains to be examined. It is interesting to note, however, that the degree of immunosuppression by the virus is not associated fa Is significantly associated with the development of therapeutic malignancy.2 considerations due to the low number of reported HIV-F Lle in the APL were no guidelines have been published VER Describes Ans tze To health care in this situation. Of course, the nature of these two diseases and related treatments myelosuppressive a big challenge for the management of e.
However, the agent in APL as ATRA and arsenic trioxide and anti-retroviral drugs such as protease inhibitors used has been shown that effects that are potentially on k Both diagnoses may overlap. Retino sour The all-trans retino S Acid The all-trans, a standard therapy in the induction, consolidation and maintenance therapy of APL has been used. Its mechanism of action includes the terminal differentiation of malignant promyelocytes into mature neutrophils in after 24 hours as described in CR andtreatment 11 results in 92% to 95% of patients with this disease.12 Of the seven F Cases here, six F Lle, including a pr presents, documents the treatment with ATRA or in combination with anthracyclines or cytarabine, 8,13,14 or as a single agent in induction.3 were 15 complete remission in all 6 F cases reached. In the one case of Maraviroc Gatphoh and colleagues, in which ATRA was not reported, no CR was achieved.16 vitro studies, an interaction between ATRA and leukemia have Demonstrated mie cells infected with HIV. In a study of bread and his colleagues have found that ATRA regulate mRNA transcription of HIV infection in human cells with HIV PML without a corresponding increase in viral replication. In contrast, mRNA translation and HIV.