Research studies on the epidemiology of AKI must address a number of unique methodological challenges,

which have the potential to impact study results and validity. This review explores several methodological issues relevant to the design and conduct of observational studies that employ preexisting laboratory, administrative or research databases and that examine AKI as an outcome or an exposure. We discuss how methodological decisions may affect study results, particularly as they relate to selection bias, misclassification and confounding. Highlighting these areas may facilitate the design of studies of high methodological rigor that advance our understanding of AKI.”
“Purpose of reviewThis review will empower the primary care provider (PCP) to evaluate, manage, and refer as needed adolescents with dysmenorrhea and/or https://www.selleckchem.com/products/citarinostat-acy-241.html chronic pelvic pain (CPP) who are suspected to have endometriosis.Recent findingsEndometriosis is a common cause of CPP in adolescents who do not respond to primary medical treatment. The presentation in adolescents is unique, causing high

rates of misdiagnosis or delayed treatment. Endometriosis-related pain has a marked negative impact on social and mental health. Simple treatments that are available in the primary care setting can alleviate pain and improve quality of life for these young women if initiated in a timely fashion.SummaryAdolescents usually turn to their PCP for evaluation

of dysmenorrhea and CPP. By maintaining a high selleck inhibitor index of TPX-0005 supplier suspicion, initiating treatment, and referring when needed, the PCP can have a tremendous effect on the patient’s present and future quality of life.”
“Most preterm babies with a gestational age less than 23-27 weeks need a respiratory support in the delivery room (DR); the aim of ventilation is to create and maintain a functional residual capacity (FRC); to facilitate gas exchange and to minimize acute lung injury. The application of a continuous positive airway pressure (CPAP) from the first breaths helps in obtaining a lung volume stabilization. Efficacy and safety of the application of a sustained lung inflation (SLI) at birth is still under careful evaluation. The prompt increase of the hearth rate and oxygen saturation in the preliminary studies at the moment available in the literature are signs of the good efficacy of the manoeuvre but the effects of the SLI on oxygenation and hemodynamics are undetermined. When preterm infants need respiratory assistance in the DR, respiratory function monitoring is desirable to apply adequate and gentle resuscitation manoeuvres. Clinical large trials taking place in the DR are needed but they are also extremely difficult to be designed and performed.