Narici et al. have pointed out that some of this variability may be attributable to differences in the age range between animal groups as well as due to measurement artifacts

associated with clamping of the excised tendons [62]. Human studies of tendon properties have until recently been hindered by requirements for cadaver donors and have been somewhat scarce. To study tendon properties in vivo, a technique has been developed based on longitudinal measurement of tendon deformation by imaging ultrasound during an isometric muscle contraction [63]. Initial studies QNZ molecular weight using this technique compared young and elderly groups, observing that tendons from older subjects were on the order of 15% more compliant [62]. The observation

that the tendons from the young and older subjects had approximately similar dimensions supported the idea that the observed differences could be attributed to differences in mechanical properties. In addition to the observation that older tendons have lower stiffness than tendons from younger subjects, there is also evidence that tendon stiffness can be increased through exercise training [64]. The ability to increase the stiffness of tendons would improve mobility by Idasanutlin molecular weight allowing for faster generation of force on bone, reducing the power and metabolic requirements on SAHA research buy skeletal muscle tissue. Narici et al. have presented excellent reviews of the literature on age-related changes in human tendon mechanical properties [62, 65]. Clinical manifestations of sarcopenia With aging, multiple processes occurring within muscle tissue, such as denervation, changes in the hormonal and inflammatory environment, mitochondrial dysfunction, and changes in the expression of regulatory factors affecting the fate of satellite Montelukast Sodium cells, combine to produce losses in the bulk properties of muscle tissue such as muscle mass and strength. Among the elderly, these changes may eventually result in loss of mobility and independence and increased risk of injury. Loss of muscle

power Age-related loss of skeletal muscle contractile power, which is essential to human motions such as rising from a chair or climbing a flight of stairs, is one of the clinical consequences most commonly linked with sarcopenia. The decline in muscle power has been established in both genders, under multiple loading conditions, in multiple limbs, and in both cross-sectional and longitudinal studies [17]. The most important anatomic sites for muscle function measurement have primarily been in the lower body, as the muscles in these sites are critical for daily function and allow for closest comparison to biopsy data. Further, power and strength losses in the lower limbs confer the largest risk factors for falls and other sources of injury and disability [66, 67]. Lower-limb power and strength are often measured using knee extension and flexion.