International Journal of Medical Microbiology 2008, in press. 13. Brown DFJ, Kothari D: The reliability of methicillin sensitivity tests on four culture media. J Clin Pathol 1974,27(5):420–426.CrossRefPubMed 14. Madiraju MV, Brunner DP, Wilkinson BJ: Effects of temperature, NaCl, and methicillin on penicillin-binding proteins, growth, peptidoglycan synthesis, and autolysis in methicillin-resistant Staphylococcus aureus. Antimicrob RAD001 manufacturer Agents Chemother 1987,31(11):1727–1733.PubMed 15. de Lencastre H, Tomasz A: Reassessment of the number of auxiliary genes essential for expression of high-level

methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 1994,38(11):2590–2598.PubMed GKT137831 16. de Lencastre H, Wu SW, Pinho MG, Ludovice AM, Filipe S, Gardete S, Sobral R, Gill S, Chung

M, Tomasz A: Antibiotic resistance as a stress response: Complete sequencing of a large number of chromosomal RO4929097 loci in Staphylococcus aureus strain COL that impact on the expression of resistance to methicillin. Microb Drug Resist 1999,5(3):163–175.CrossRefPubMed 17. Berger-Bachi B, Rohrer S: Factors influencing methicillin resistance in staphylococci. Arch Microbiol 2002, 178:165–171.CrossRefPubMed 18. Rohrer S, Berger-Bachi B: FemABX peptidyl transferases: A Link between branched-chain cell wall peptide formation and β-lactam resistance in gram-positive cocci. Antimicrob Agents Chemother 2003,47(3):837–846.CrossRefPubMed 19. Piriz Duran S, Kayser FH, Berger-Bachi B: Impact of sar and agr on methicillin resistance in Staphylococcus aureus. FEMS Microbiol Lett 1996, 141:255–260.CrossRefPubMed 20. Wu Niclosamide S, de Lencastre H, Tomasz A: Sigma-B, a putative operon encoding alternate sigma factor of Staphylococcus aureus RNA polymerase: molecular

cloning and DNA sequencing. J Bacteriol 1996,178(20):6036–6042.PubMed 21. Seidl K, Stucki M, Ruegg M, Goerke C, Wolz C, Harris L, Berger-Bachi B, Bischoff M:Staphylococcus aureus CcpA affects virulence determinant production and antibiotic resistance. Antimicrob Agents Chemother 2006,50(4):1183–1194.CrossRefPubMed 22. Kuroda M, Kuroda H, Oshima T, Takeuchi F, Mori H, Hiramatsu K: Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus. Mol Microbiol 2003,49(3):807–821.CrossRefPubMed 23. Ender M, Berger-Bachi B, McCallum N: Variability in SCC mec N1 spreading among injection drug users in Zurich, Switzerland. BMC Microbiology 2007.,7(62): 24. Qi W, Ender M, O’Brien F, Imhof A, Ruef C, McCallum N, Berger-Bachi B: Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Zurich, Switzerland (2003): Prevalence of type IV SCC mec and a new SCC mec element associated with isolates from intravenous drug users. J Clin Microbiol 2005,43(10):5164–5170.CrossRefPubMed 25.