However, future studies will be needed to determine the effectiveness of delivering such an exercise programme without the regular contact and support of a research team. Nevertheless, this innovative mode of programme delivery possesses the www.selleckchem.com/products/ganetespib-sta-9090.html potential for broad-scale dissemination and should be well-received by those affected by chronic disabling diseases due to its progressive and modifiable nature. Supplementary Material Author’s manuscript: Click here to view.(3.7M, pdf) Reviewer comments: Click here to view.(162K, pdf) Acknowledgments The authors express their appreciation to: Ruth Franklin Sosnoff,

PhD, and Julia Balto, project coordinators; Bill Yauch of RiellyBoy Productions; Erica Urrego, FlexToBa DVD exercise leader; and Grant Henry, Lynda Matejkowski, Joyce O’Donnell,

Bernard Puglisi, Paula Smith, and Peter Tan, FlexToBa DVD exercise models. The authors also extend their thanks to Andrew Weil, MD, for the generous contribution of the Healthy Aging DVDs. Footnotes Contributors: TRW contributed to the conception and design of the study, led programme orientation sessions, assisted with the acquisition of data, and drafted and revised the manuscript. SAR led programme orientation sessions, assisted with the acquisition of data, and helped to draft and revise the manuscript. YCL assisted with the acquisition of data, designed and will conduct the qualitative assessments, and contributed to the writing and revision of the manuscript. EAH and DK-H assisted with the acquisition of data, were responsible for conducting onsite assessments and interviews, and helped to draft and revise the manuscript. RWM contributed to the conception and design of the study, assisted with the acquisition of data, and helped to draft and revise the manuscript. EM conceived the study, made substantial contributions to its design, and contributed to the drafting and revision of the manuscript. All authors read and approved the final version of the submitted

Entinostat manuscript. Funding: This project is supported by grant number IL0009 from the National Multiple Sclerosis Society. Competing interests: None. Patient consent: Obtained. Ethics approval: The study protocol was approved by the University of Illinois at Urbana-Champaign’s Institutional Review Board (Urbana, Illinois, USA; Protocol No. 14163). Provenance and peer review: Not commissioned; externally peer reviewed.
The context of healthcare in the UK is changing, with an increasingly aging population and a growing focus on the prevention and management of disease.1 This has prompted the need to ensure that medical graduates are adequately prepared to address these evolving healthcare needs, rather than maintaining a reactive approach to illness in the UK.