In this study of a cohort of about 100,000 pregnancies and more than 1,100 S Infants exposed to either beta-blockers or calcium channel blockers, we observed an apparent Erh Increase the risk of you beg Cases in S Uglingen whose mothers w under calcium channel blockers during pregnancy and incrhypoglycaemia simple chemistry Among children whose mothers took beta blockers w During pregnancy. It that these risks have been measured in the perinatal period, there was no attempt to fill the risk of l Ngere vision or long-term effects of either Clinofibrate Lipoclin neonatal Krampfanf Or hypoglycaemia Measure chemistry. There was no increased HTES risk of congenital malformations in children exposed to either calcium channel blockers or beta blockers. In addition to a risk category, we looked at the selection stage of the analysis, h Dermatological diseases, we did not find evidence of a severe disease associated with consistent exposure. Beta-blockers can k Cross the placenta and uglingen physiological effects in S, Including normal increased FITTINGS exercise insulin levels and reduced glucagon26, 27 These two actions potentially hypoglycaemia mie Lead in children.
Hypoglycaemia Chemistry is an h Ufiges problem neonatal metabolism and in most cases Cases it is obvious Aufl TFollow solution and without Sp. A recent systematic verification of neonatal hypoglycaemia Chemistry and neurological development sp Ter was a significant Ver Change in the studies that AP23573 have examined this relationship28. If l Prolonged or severe hypoglycaemia Premiums k Can enter dinner severe neurological consequences such as a study of more than 600 infants29 shown. Especially Hypoglyc mie Urgent development of neurological and psychological influences motor, and was associated with a reduction of 13 and 14 points in the mental and motor development at 18 months.
Moreover, the risk of cerebral palsy or Entwicklungsverz Delay 3.5-fold in S Uglingen with extended Ngerter neonatal hypoglycaemia Mie erh Ht. One drawback of our study is that it provides no information on the duration of hypoglycaemia Chemistry, and therefore we are not in a position to know whether beta-blockers with hypoglycaemia Mie L Ngeren and / or severe, respectively. Such as beta blockers, calcium channel blockers can also cross the placenta and k Can Dinner registered a decrease in intracellular Ren infant30 calcium, 31 In both adults and children is toxicity Connected t calcium antagonists with seizures32. Moreover Hypokalz Mie a known cause of neonatal beg Lle, and Neonatal beg Ll usually work includes checking a serum calcium level33.
Neonatal Anf lle Due Hypokalz Chemistry are generally associated with endocrine abnormalities either newborn or the mother, as the disease parathyro, Or diabetes. Hypokalz Mie is also in S Uglingen diabetic mothers seen, and is h More frequently and severe, severe maternal diabetes and glucose abnormalities34. Neonatal beg Lle can particularly severe and may be associated with a poor neurological development of the child, h hangs from the etiology The seizures33. Most newborns beg Ll be. By serious problems, such as meningitis or encephalopathy hypoxicischemic caused in itself associated with a poor neurological outcome According to the summary procedure, neonatal neurology group Kr Cramps, early lle The most important sign of acute encephalopathy35 Newborns and are an independent-Dependent and important risk factor for death or neurological disability sp Ter.