Ah, the local scene of the tumor and those treated stage IV, this study includes more than twice as many patients as in previous studies. We believe that the difference CAY10505 of EFS in the current study showed realfor is for several reasons. First, although only patients in our study in the CT treatment only receiveddrug group were included, the percentage EFS found here compared with the percentage of RFS indicated, patients with pulmonary L emissions by R ntgenuntersuchung the breast detected with the two drugs treated NWTSbefore The advent of doxorubicin. This result suggests that Is similar poor outcome in this group and increased in real terms Ht confidence in the accuracy of the results for the current group of patients only.
Secondly, the advantage of using intensive chemotherapy in patients with dumplings tchen CT alone was also supported by the results of the children in the K Proposed Kingdom, tumors of the latter s Wilms Cancer Study Group study of which found that patients with stage I who were usually treated with vincristine alone were an hour had here recidivism rate, if L emissions were only available CT. Third, the Pr Prevalence of pulmonary recurrences in the group with only two drugs in the treatment dealt with in accordance with Lungensch Ending CT alone. W While the addition of doxorubicin with improved EFS was assigned in this report, was not significantly influenced OS. Given the high rate of the OS, it is m possible that the sample size was insufficient for detecting small increase in survival rate.
Otherwise k nnte The year OS not because the F Ability, to save patients with recurrent disease may be affected. However, k can The results of two studies at low and high risk of relapse NWTSsuggest onlyof this low-risk patients are at high risk andof restored, which implies that an improvement in EFS should result in a better operating system. It is also Possible that the increased Hte survival rate by treatment with three drugs caused by an increase in Todesf Lle is toxic doxorubicin Andor RT pulmonary balanced, but do not support the data indicates that M Opportunity with the majority of Todesf lle in the two groups on the basis of the tumor. Our data do not show an advantage for patients with dumplings tchen CT only on bilateral pulmonary radiotherapy.
Although there is a trend towards improved EFS rate of patients U lung RT, this trend is again completely Ndig disappeared, though the results were adjusted for chemotherapy. These results are in contrast with that of Nicolin et al. based on the VHF and VHF studies were with fa A randomized phase IV than patients without lung irradiation were treated in a less good result despite the fact that all three drugs confinement Lich doxorubicin treated atmgm. The gr-Run difference between this study Gro Britain and the n Is that the British study included children with pulmonary metastases detected by R Ntgen-ray, in contrast to our study, the emissions are included only patients with pulmonary L Small enough to be detected on CT. The interpretation of these combined studies is that patients with lung metastases at any size E, benefit from the addition of two drug doxorubicin therapy, but pulmonary irradiation may be beneficial for a gr Ere sions L. Unfortunately, none of this retrospective study to define the boundaries of these categories