By scanning each color separately, differential gene expression can be assessed in an internally controlled manner. This method of gene expression analysis is a convenient way to compare the efficacy and side effects of drug candidates: cultured cells or animals are treated with several drug candidates that, share a common mechanism. A {Selleck Anti-diabetic Compound Library|Selleck Antidiabetic Compound Library|Selleck Anti-diabetic Compound Library|Selleck Antidiabetic Compound Library|Selleckchem Anti-diabetic Compound Library|Selleckchem Antidiabetic Compound Library|Selleckchem Anti-diabetic Compound Library|Selleckchem Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|buy Anti-diabetic Compound Library|Anti-diabetic Compound Library ic50|Anti-diabetic Compound Library price|Anti-diabetic Compound Library cost|Anti-diabetic Compound Library solubility dmso|Anti-diabetic Compound Library purchase|Anti-diabetic Compound Library manufacturer|Anti-diabetic Compound Library research buy|Anti-diabetic Compound Library order|Anti-diabetic Compound Library mouse|Anti-diabetic Compound Library chemical structure|Anti-diabetic Compound Library mw|Anti-diabetic Compound Library molecular weight|Anti-diabetic Compound Library datasheet|Anti-diabetic Compound Library supplier|Anti-diabetic Compound Library in vitro|Anti-diabetic Compound Library cell line|Anti-diabetic Compound Library concentration|Anti-diabetic Compound Library nmr|Anti-diabetic Compound Library in vivo|Anti-diabetic Compound Library clinical trial|Anti-diabetic Compound Library cell assay|Anti-diabetic Compound Library screening|Anti-diabetic Compound Library high throughput|buy Antidiabetic Compound Library|Antidiabetic Compound Library ic50|Antidiabetic Compound Library price|Antidiabetic Compound Library cost|Antidiabetic Compound Library solubility dmso|Antidiabetic Compound Library purchase|Antidiabetic Compound Library manufacturer|Antidiabetic Compound Library research buy|Antidiabetic Compound Library order|Antidiabetic Compound Library chemical structure|Antidiabetic Compound Library datasheet|Antidiabetic Compound Library supplier|Antidiabetic Compound Library in vitro|Antidiabetic Compound Library cell line|Antidiabetic Compound Library concentration|Antidiabetic Compound Library clinical trial|Antidiabetic Compound Library cell assay|Antidiabetic Compound Library screening|Antidiabetic Compound Library high throughput|Anti-diabetic Compound high throughput screening| comparison of gene expression changes often reveals changes that Inhibitors,research,lifescience,medical are mechanism-related and are shared by such compounds, as well as changes that are
peculiar to one compound and suggest, that the compound has side effects. Such analyses can help clarify the therapeutic mechanism of action of drugs. Oligonucleotide arrays, upon which sets of oligonucleotides represent different alleles of an SNP, are used for the analysis of DNA variation. Inhibitors,research,lifescience,medical In this way, thousands of SNPs can be read out automatically and rapidly63,64 By applying whole-genome SNP LD mapping to patients during phase 2 clinical trials of a drug, it may be possible to select multiple small regions from the whole-genome Inhibitors,research,lifescience,medical SNP map where SNPs are in LD and associated with efficacy and common adverse
event, phenotypes. Selecting only these small regions of SNP LD into abbreviated SNP LD profiles will enable more rapid and inexpensive screening of patients who are likely to experience efficacy or ADRs in response to that drug.65 Thus, whereas the phase 2 SNP scan might, genotype up to 200 000 SNPs for each patient,66 the critical data, used for identifying markers for efficacy for subsequent, phase 3 clinical trials may use only several hundred SNPs from Inhibitors,research,lifescience,medical multiple small regions in LD associated with efficacy or ADRs. The cost of chips as a platform for drug response
profiling is likely to be reduced when analyses of hundreds of thousands of patients are performed once the medicine is marketed. In fact, each chip could contain a panel of abbreviated SNP LD profiles for several drugs with the same clinical indications, Inhibitors,research,lifescience,medical so that the most appropriate medicine with that indication for that patient can be determined from Astemizole a single blood sample. Competition in the biotechnology sector to develop industrial genotyping capacity has reduced the retail price of genotyping some SNPs from US1 to US0.10 per SNP within 1 year,12 and the prediction is a continued decrease in price to less than US$0.01. There are ongoing technological developments, eg, the extraction of DNA from a few cells, from a buccal swab, and for the amplification of human DNA and RNA, in order to produce sufficient, quantities from minute samples (eg, GenomiPhi®, Amersham). This will circumvent, the need for a blood sample and make individual sampling even easier. One can predict that, in the future, metabolic screens of genetic variants will be standardized so that automated read-outs of each person’s predicted response to each medicine can be generated.