clinical development has been challenging, the next few years will yield important information as results from the randomized phase III trials further define the role of 90Y in treatment algorithms. “
“Background and Aim: The role of pancreatic duct (PD) stenting in patients undergoing endoscopic transmural drainage of peripancreatic fluid collection (PFC) remains unclear. The objective of this study is to evaluate the effect of PD stenting on treatment success Tamoxifen mouse in patients undergoing endoscopic transmural drainage of PFC. Methods: This is a retrospective follow-up study of all patients who underwent endoscopic and endoscopic ultrasonography-guided transmural drainage of PFC during a 5-year period.
Double-pigtail stents were deployed in all patients; in addition, nasocystic catheters were deployed in those with abscess/necrosis. An endoscopic retrograde cholangiopancreatogram was attempted whenever feasible in all patients, and pancreatic stents were placed when the duct disruption could be bridged. Success http://www.selleckchem.com/products/Decitabine.html was defined as an improvement in symptoms and resolution of PFC upon follow-up computed tomography at 8 weeks. Results: Of the 110 patients who underwent PFC drainage, 40 (36%) underwent simultaneous PD stenting. Treatment was successful in 95 of the 110 patients (86%). The PFC types were: pseudocyst (62%), necrosis (20%), and abscess (18%). The median duration of follow up was 9.9 months. Those who underwent PD stenting were significantly more likely to have treatment success than those who did not undergo PD stenting (97.5% vs 80%; risk ratio [RR]crude = 1.48, P = 0.01). In the multivariable analysis, this association
MCE公司 remained significant (RRadjusted = 1.14, 95% confidence interval: 1.01–1.29, P = 0.036), even after adjusting for the etiology of pancreatitis, type and location of PFC, luminal compression at endoscopy, enteral nutrition, white blood cell count, and number of endoscopic interventions. Conclusions: Transpapillary PD stenting improves treatment outcomes in patients undergoing endoscopic transmural drainage of PFC. “
“Inflammatory bowel disease (IBD) incidence and prevalence have increased dramatically since the middle of the 20th century, particularly in Western countries. However, with 60% of the world’s population living in Asia, the impact of an increase in IBD incidence in this continent would represent an enormous increase in the absolute numbers of patients with these diseases. Since early reports of IBD in Asia, the implications of an IBD epidemic in the world’s most populous continent has concerned both clinicians and scientists.