31) In addition to the use of standard therapy for heart failure (diuretics, http://www.selleckchem.com/products/Enzastaurin.html vasodilators and digoxin), prolactin inhibition32) may provide potential benefit to patients with peripartum cardiomyopathy. Careful attention must be paid to select drugs relatively safe for mother and fetus and to exclude those that can evoke fetal abnormalities. The duration of treatment is still unknown. Though the majority of peripartum cardiomyopathy patients recover partially or are completely improved with treatment, the reported mortality rates lie between 18% and 56%.26),33)
Inhibitors,research,lifescience,medical Moreover, subsequent pregnancy in these patients can be associated with a recurrence of peripartum cardiomyopathy and can result in death.33) Stress-induced cardiomyopathy Inhibitors,research,lifescience,medical SCMP is a syndrome of reversible LV systolic dysfunction with characteristic apical ballooning in patients without significant epicardial coronary artery stenosis.10),34) This syndrome, also known as Takotsubo cardiomyopathy, is believed to be associated Inhibitors,research,lifescience,medical with various clinical scenarios, especially with intense mental or emotional stress.35) However, physical stress can cause this kind of cardiomyopathy. Park et al.35) reported their data of patients admitted to the medical intensive care unit.
They reported 28% of patients showed apical ballooning and they were usually Inhibitors,research,lifescience,medical associated with hypotension, sepsis, cardiomegaly and use of inotropic agents. SCMP occurs usually in
women over 50 years of age, and the typical features include profound mental stress immediately preceding and triggering the cardiac events, acute retrosternal chest pain with ST-segment change and/or T-wave inversion, absence of significant coronary artery stenosis by coronary angiography, and LV systolic dysfunction with abnormal wall motion of Inhibitors,research,lifescience,medical apex (apical ballooning).11) There is a variant of apical ballooning syndrome. Transient mid- and basal-ventricular ballooning is a new variant of the transient LV apical ballooning syndrome. The involvement of the LV’s mid- and basal-ventricle with sparing GSK-3 of the apical segment is the unique finding of this variant.36) Because the guideline excludes the presence of pheochromocytoma in the diagnosis of SCMP, the presence of a specific pattern with pheochromocytoma should be classified as catecholamine-induced cardiomyopathy.37) Echocardiography is a useful method to diagnose this type of cardiomyopathy. Transthoracic echocardiography usually demonstrates LV systolic dysfunction with typical apical ballooning and/or midventricular hypokinesia, and the wall-motion abnormality extends beyond the http://www.selleckchem.com/products/dorsomorphin-2hcl.html distribution of any of one single coronary artery.10),11) Transient LV hypokinesia can be restricted to the midventricular segment and/or basal segment without involvement of the apical segment in a minor population.