258), physical (p = 0.232), emotional (p = 0.295), social (p = 0.464), school (p = 0.502), and

psychosocial domains (p = 0.473), as well as overall quality of life (p = 0.291). However, in the post-test, there was a difference between groups in the physical (p < 0.001), emotional (p = 0.030), social (p = 0.007), and psychosocial (p = 0.002) domains, as well as overall quality of life (p < 0.001), with higher values in the case group. The groups did not differ in BMI (p = 0.060) and in the school domain of quality of life (p = 0.201) in the post-test period. It was observed that the case group presented, at the end of the program, a significant reduction in BMI (p = 0.001), from 26.4 kg/m2 (95% CI = 24.55 to 28.59) to 25.5 kg/m2 (95% CI = 23.47 to 27.54). Although there was no statistically significant difference (p = SRT1720 molecular weight 0.078), the BMI of the control group increased from 28.3 kg/m2 (95% CI = 25.62 to 31.14) to 28.7 kg/m2 (95% CI = 25.98 to 31.47). All children remained above the 97th percentile.16 Table 1 shows the results of the program impact on the health-related quality of life domains. It was observed that the case group Afatinib mw showed significant improvement in the physical, emotional, social, and psychosocial domains, as well as overall quality of

life, according to self-reporting by the children. There were no changes in these variables in the control group. The present study demonstrates the importance of a multidisciplinary intervention on the health-related quality of life of obese children, showing effects in the reduction of BMI and improvement in quality tuclazepam of life, especially in the physical, emotional, social, and psychosocial domains, as well as in overall quality of life. One of the strengths of this study

was that the sample was gender- and age-matched, minimizing the possible influence of these variables on the investigated parameters.3 The suggested exercises were playful and recreational, showing that this type of activity, when accompanied by nutritional counseling, also has positive effects on obese children. Despite different methodologies, studies have demonstrated the positive effects of intervention programs on the quality of life of obese children, which is in agreement with the results of this study.3, 10, 14 and 15 The present findings are clinically important due to the negative impact of obesity on quality of life, which can be similar to that of children with cancer undergoing chemotherapy,26 when evaluated using the same methodology. This suggests that advances in certain areas may represent a significant improvement on the daily routine of obese children, especially regarding their self-esteem, social relationships, and daily activities.