, 2006). Research suggests that the underlying mechanisms of manual therapy may be multifactorial, including such elements as decreased spinal stiffness and improved lumbar multifidus muscle recruitment ( Fritz et al., 2011). Osteopathic medicine

has integrated manual therapy techniques, collectively known as osteopathic manual treatment (OMT), into its system of health care (Mein et al., INNO-406 concentration 2001). Osteopathic physicians are an important source of medical care for chronic LBP in the United States, providing one-third of medical visits for this condition (Licciardone, 2008). The results of the OSTEOPATHIC Trial recently demonstrated statistically significant and clinically relevant improvements in patients with chronic LBP following a short-term, multimodal OMT regimen (Licciardone et al., 2013b and Licciardone et al., 2013c). The purpose of the present study was Compound Library to perform secondary analyses of the OSTEOPATHIC Trial data to measure changes in biomechanical dysfunction following OMT and to assess how such changes predict subsequent chronic LBP outcomes. The methodology and outcomes of the OSTEOPATHIC Trial have been reported elsewhere (Licciardone et al., 2008, Licciardone and Kearns, 2012, Licciardone et al., 2012a, Licciardone

et al., 2012b, Licciardone et al., 2013a, Licciardone et al., 2013b and Licciardone et al., 2013c). The trial featured a randomized, double-blind, sham-controlled, 2 × 2 factorial design to study OMT and ultrasound therapy over 12 weeks in patients with nonspecific chronic LBP. Patients were SSR128129E recruited within Dallas-Fort Worth from August 2006 to September 2010 through newspaper advertisements, community agencies, and medical clinics. Patients 21–69 years of age were eligible to participate if they reported having LBP most days in the past three months. Patients were excluded if they reported “red

flags” suggesting serious underlying conditions as the cause of LBP (Bigos et al., 1994). These included history of any of the following: cancer; unexplained weight loss; immunosuppression; urinary infection; intravenous drug use; prolonged use of corticosteroids; spinal fracture or significant trauma; urinary retention or overflow incontinence; loss of anal sphincter tone or fecal incontinence; saddle anesthesia; or global or progressive motor weakness in the lower extremities. Patients were also excluded if they reported history of any of the following: recent low back surgery; receipt of worker’s compensation benefits or ongoing litigation involving back problems; medical conditions that might impede OMT (or ultrasound therapy) protocol implementation; corticosteroid use in the past month; or use of manual therapy in the past three months or more than three times in the past year.