This strategic interaction makes CBD as a potential candidate

for the development of a new class of anti-IBD drugs. Copyright (c) 2012 John Wiley & Sons, Ltd.”
“Ingestion of arsenic (As) through contaminated drinking water results in increased risks of skin, lung, kidney, and bladder cancers. Due to its association with kidney and bladder cancers, we hypothesized that analysis of the urinary proteome could provide insight into the mechanisms of As toxicity. Urine from participants in a cross-sectional As biomarker study conducted in Nevada, classified as having either high (>= 100 mu g total urinary As/l) or low exposure (< 100 mu g total urinary As/l) was analyzed by surface-enhanced laser desorption/ionization OSI-906 solubility dmso time-of-flight mass spectrometry. Two polypeptides, 2.21 and 4.37 kDa, were significantly decreased in the high exposure group (p < 0.05) and were limited to men when stratified by sex. To replicate these findings, urine from participants in a second As study in Chile was analyzed and results confirmed the decrease of the 4.37 kDa polypeptide as well as a 4.76 kDa polypeptide among highly exposed men. These peaks were identified and confirmed as human beta-defensin-1 (HBD-1) peptides. In

a separate in vitro experiment, gene expression analysis of As-treated cell lines demonstrated reduced HBD1 mRNA confirming that the observed decrease in HBD-1 resulted from As exposure. HBD-1 is an antimicrobial peptide constitutively expressed in U0126 MK-8776 cell line multiple tissues including epithelial cells of the respiratory and urogenital systems. Recent studies support its role as a tumor suppressor gene for urological cancers suggesting that decreased HBD-1 levels may play a role in the development of cancers associated with As exposure. Further studies are warranted to investigate the role of HBD-1 in As-related toxicity.”
“Background: Aging promotes neuromuscular loss, significantly

reducing muscle strength. The magnitude of loss of strength seems to be different between the limbs, probably because of differences in activities of daily living (ADL). Therefore, the present study compared the muscle strength of the elbow flexors and knee extensors in younger (n = 7, mean age 23.3 +/- 1.2 years) and older (n = 5, mean age 61.8 +/- 2.6 years) men matched by ADL level.\n\nMethods: The study participants performed maximal concentric, isometric, and eccentric contractions of the elbow flexors and knee extensors using an isokinetic dynamometer following a crossover study design. Changes in the dependent variables were compared using mixed model analysis (limb versus age).\n\nResults: The main results demonstrated that concentric, eccentric, and mean contraction torques for knee extensors were significantly (P > 0.05) higher for younger men than for elderly men. On the other hand, no statistically significant difference (P > 0.