24 [1.18, 1.30], p < .001; lifetime: OR = 1.25 blog of sinaling pathways [1.19, 1.30], p < .001). For males, increasing SS by one point and one SD increased the odds of past 30-day smoking by 39% (lifetime, 36%) and 253% (lifetime 250%), respectively; a male participant with the maximum SS score of 16 was about 192 (lifetime 131) times more likely to have smoked in the past 30 days than one with the minimum score of 0. For females, one point and one SD increases in SS were associated with 24% and 138% increases in the probability of past 30-day smoking and 25% and 147% in the probability of lifetime smoking. A female participant with the maximum SS score was 29 times more likely to have smoked in the past 30 days and 34 times more likely in her lifetime, than one with the minimum score.

Simple Mediational Models Results from the simple meditational models are shown in Table 2. For both 30-day smoking models, the a (associations between SS and mediators) and b (associations between mediators and smoking) paths were significant. We found that both negative affect (ab = 0.11, 95% CI 0.09, 0.14) and risk perceptions (ab = 0.06, 95% CI 0.03, 0.09) were significant mediators of the relationship between SS and past 30-day smoking. For lifetime smoking, the a and b paths were again significant for both models. Additionally, negative affect (ab = 0.05, 95% CI 0.03, 0.06) and risk perceptions (ab = 0.06, 95% CI 0.04, 0.08) each mediated the relationship between SS and lifetime smoking. Table 2.

Mediational Models for Past 30-Day and Lifetime Smoking Multiple Mediation Model To assess the effects of negative affect and risk perceptions together, we then fit multiple mediation models for both 30-day and lifetime smoking (see Table 3 and Figure 1). For past 30-day smoking, the specific indirect effects of both negative affect (z = 3.40, p < .001) and risk perceptions (z = 4.33, p < .001) were significant. The combined indirect effect was also significant (z = 5.38, p < .001). Similarly, for the lifetime smoking model, indirect effects of negative affect (z = 3.25, p = .001) and risk perceptions (z = 4.51, p < .001) and the combined indirect effect (z = 6.14, p < .001) were all significant. The indirect effects of negative affect and risk perceptions were not significantly Dacomitinib different from each other in either model. Table 3. Multiple Mediation Model of the Indirect Relationship Between Sensation Seeking and Past 30-Day and Lifetime Smoking Figure 1. Indirect effects of sensation seeking on past 30-day and lifetime smoking through negative affect and risk perceptions. Note: Regression coefficients (standard errors) depicted above each arrow are for past 30-day smoking; coefficients (standard errors) …