eradication; 3. first-line; 4. triple therapy; Presenting Author: XIUQING WEI Additional Authors: YUNWEI GUO, HUIXIN HE, WEI MAO, BIN WU Corresponding Author: XIUQING WEI Affiliations:

Department of Digestive Disease, Third Affiliatted Hospital of Zhongshan University Objective: Bismuth based quadruple therapy is a preferred option as a choice of first-line eradication failures. However, bismuth is not currently available in many countries. STI571 concentration Management of first-line eradication failures is becoming challenging. The aim of this study was to test whether a two-week triple therapy regimen containing esomeprazole, amoxicillin and furazolidone can serve as an alternative rescue therapy regimen. Methods: This study included 121 patients with gastritis or peptic ulcer disease with a recent history of failed Helicobacter pylori eradication therapy with a pump inhibitor + clarithromycin + amoxicillin (Group A) or a pump inhibitor + clarithromycin + metronidazole

(Group B) for the first time. The eradication therapy consisted of a 2-week twice daily oral administration of esomeprazole 20 mg, amoxicillin 1000 mg, furazolidone 200 mg. Therapeutic success was confirmed by a negative 13C- selleck chemical urea breath test performed four to eight weeks after cessation of therapy. Results: By the intention-to-treat (ITT) analysis, the Helicobacter pylori eradication rates and 95% confidence intervals (95% CI) of the overall, Group A and Group B were 81.8% (95% CI: 74.9%–88.7%), 84.1% (95% CI: 77.5%–90.6%) and 78.9% (95% CI: 71.6%–86.1%). By the per protocol (PP) analyses, the Helicobacter pylori eradication rates and 95% confidence intervals

(95% CI) of the overall, Group A and Group B were 88.4% (95% CI: 82.7%–91.6%), 90.6% (95% CI: 85.4%–95.8%) and 85.4% (95% CI: 79.1%–91.7%). There were no significant differences of the eradication rates between group A and group B by both intention-to-treat (ITT) and per protocol (PP) analyses (P = 0.462 for ITT, P = 0.394 for PP). Conclusion: The selleck products two-week triple therapy regimen containing esomeprazole, amoxicillin and furazolidone can serve as a rescue therapy regimen for patients with a recent history of first time treatment failure with a standard first-line therapy in our region. Acknowledgements: This study was supported by National Natural Science Foundation of China, No. 81272640; Guangdong Science and Technology Program, No. 2010B031200008 and No. 2012B031800043. Key Word(s): 1. Helicobacter pylori; 2. eradication; 3. rescue; 4.