Elasticity Imaging Techniques can selectively detect the parameters of the designated area and Speculate liver stiffness, so we get the result with less Influencing factors. In this study, We analyze the relevance between elastic shear wave velocity (ESWV) and the stage of liver fibrosis proved by biopsy. Methods: 25 patients with chronic hepatitis B were assigned to the

study group in which all the patients www.selleckchem.com/products/GDC-0980-RG7422.html suffered from Liver parenchyma diffuse lesions and without any occupying lesions. 25 healthy volunteers participated in the study (age, sex, body weight-matched), and were assigned to the control group. In early morning, in the state of fasting, Left lateral position, all the patients and volunteers accept ultrasound examination (Siemens s2000, probe 4s-1). For each

subject, we select 3 different regions 5 cm depth in liver tissue, and record the ESWV 10 times in each region, then get the average value. Patients underwent liver biopsy later. We analysis the correlation between the ESWV and the histological fibrosis staging obtained by liver biopsy. Results: For healthy volunteers, the ESWV are all less than 1.45 (1.01 ± 0.23), while the ESWV are no less than 1.15(2.01 ± 0.76) in study group. There is significant differences between the two groups (p < 0.05). proved by biopsy, F1:7 (1.25 ± 0.29); NU7441 F2:5 selleckchem (1.31 ± 0.39); F3:5 (1.48 ± 0.34), F4:8 (2.31 ± 0.54). Receiver-operating characteristic curve according to the value of 1.38 of ESWV showed a sensitivity of 83.6% and a specificity of 90.8% for the presence of liver fibrosis. Conclusion: ESWV

highly correlate with liver parenchyma fibrosis and ESWV is a reliable predictor of liver fibrosis, especially for the fibrosis stage F2 or even higher. Key Word(s): 1. liver fibrosis; 2. elastic shear wave; 3. elasticity imaging; Presenting Author: JOHN HSIANG Additional Authors: WAYNE BAI, SRIHARAN SELVARATNAM, STEPHEN GERRED, ARLO UPTON, DINESH LAL, ED GANE Corresponding Author: JOHN HSIANG Affiliations: Middlemore Hospital; Gastro Department, Middlemore Hospital; NZ Liver Unit, Auckland CIty Hospital Objective: To evaluate patient demographics, mode of presentation and outcomes of cirrhotic patients in South Auckland, New Zealand. Methods: Patient data was extracted from Middlemore Cirrhosis Database. Results: 843 cirrhotic patients were included. The incidence of Non-alcoholic fatty liver (NAFLD) cirrhosis has increased from 7.8 cases/year in first six years to 12.8 cases/year in the latter six years, over 12-year period (p = 0.02). Patients with alcohol cirrhosis are mostly likely to present symptomatically (OR 4.9, p < 0.01). Key Word(s): 1. cirrhosis; 2. liver disease; 3.